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They play a key role in: Allergic reactions Wound healing Immune defense against pathogens Regulating inflammation When activated, mast cells release granules filled with bioactive substances, including: Histamine Tryptase Prostaglandins Leukotrienes Cytokines This process is called degranulation and in normal situations (e.g., in response to an insect sting or parasite), it's protective

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Other investigations examine cellular signaling, circadian regulation, and intracellular physiology