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In parallel, Ward and co-workers performed pioneering work where they deployed site-directed mutagenesis to delineate amino acid residues in mouse IgG Abs critical for binding to mouse FcRn [48]

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In a randomized placebo-controlled trial that included 101 participants with fibromyalgia, those who received 3 mg or 5 mg of melatonin nightly in addition to antidepressant therapy with fluoxetine had improvement on Fibromyalgia Impact Questionnaire scores after eight weeks

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