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Dosing Time-Dependent Changes in the Anti-Tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice

It directly binds to oxidative compounds that damage cell membranes, DNA and energy production

From a clinical perspective: This is why injection glutathione is often recommended initially, followed by maintenance strategies

Membranes were incubated in blocking buffer (5% skim milk, 0.1% Tween20 in Tris-buffered saline) for 1 h and probed overnight with primary antibody at 4 C

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