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Macrophages detect these apoptotic cells using specific efferocytic receptors, such as Mer tyrosine kinase (MERTK) and T-cell immunoglobulin and mucin domain containing-4 (TIM-4), which recognize PS directly or indirectly through bridging molecules like Growth Arrest-specific gene 6 (Gas6) and Protein S [24, 30]

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the reduction in Health Assessment Questionnaire Disability Index (HAQ-DI) was 0.50 at 24 weeks for the combined certolizumab pegol groups compared with 0.19 for placebo