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They mediate inflammatory responses

Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 delta Inhibitors

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In patients with osteosarcoma, which is the most common bone tumor, serum, and urinary metabolomics revealed a distinct phenotype compared to healthy patients, suggesting that downregulation of central carbon metabolism and increased glutathione metabolism were characteristic features of osteosarcoma 14

Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structureactivity relationships, lead optimization, and chronic in vivo efficacy

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