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Additionally, it is believed that an excess of homocysteine (HCy) can undergo auto-oxidation, leading to the production of hydrogen peroxide [46]

Thus, any compound that requires DMSO as solvent or at least contains a significant amount of DMSO to solubilize it needs to be injected outside the metabolism phase of APAP, which is about 1.52 h for a 300 mg/kg dose and longer with higher doses

1k,l and Extended Data Fig

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Preclinical studies using animal models or neuronal cell cultures for conditions such as Parkinson's or Alzheimer's disease often measure tissue-specific GSH levels and the GSH/GSSG ratio as key biomarkers of oxidative damage