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Any disagreements between the first two reviewers regarding extracted data were resolved through discussion by a third reviewer

It is the most popular skin lightening agent in Japan because of its ability to inhibit melanin production by inhibiting tyrosinase activity

The synthetic preparations are sequence-identical to their endogenous forms

The first five layers form the epidermis, which is the outermost, thick

Intracellular SAM, the one carbon-derived methyl donor, is synthesized by methionine and ATP in the presence of methionine adenosine transferase (Figure 1)