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For this reason, gluten is often stigmatized as responsible for alterations in human well-being and health [140]

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Jacobs et al

UA administration downregulated inflammatory cytokines/chemokine and immune cells in mice with cisplatin-induced nephrotoxicity [37] and resulted in reduced levels of the endoplasmic reticulum stress (ERS) markers, phosphorylated mitogen-activated protein kinase 8 and pro-inflammatory interleukins in obese mice [27]

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A phase 2, double-blind, placebo-controlled trial randomized patients with moderate-severe PDPN to subcutaneous fulranumab or placebo