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In normal conditions, melatonin promotes autophagy for regulating cell survival, but during hyperglycemia and oxidative stress, melatonin indirectly inhibits autophagy through alleviating oxidative stress, inflammation, and endoplasmic reticulum stress and decreasing proinflammatory cytokines and VEGF [41-42]

[Abstract]2025 Jun;48(3):1484-1498

10.1038/s41392-024-01891-4 Signal Transduct Target Ther

Producator: CosmoPharm.

It is no longer marketed as an FDA-approved finished drug

This mechanism represents a hallmark of fibromyalgia and many other chronic pain syndromes, including irritable bowel syndrome, temporomandibular disorder, migraine, and low back pain