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The virtual reactions were achieved by converting the Simplified Molecular-Input Line-Entry System (SMILES) of each molecule through SMART reaction by RDKit ( (Fig

Concurrently, DRP-104, the prodrug of DON, has been observed to promote the polarization of tumor-associated macrophages (TAMs) to the M1-TAMs phenotype

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Increasing evidence indicates that GSH plays a protective role in limiting cuproptotic cell death (Fig

To address these challenges, integrating cutting-edge technologies like metabolomics and single-cell sequencing to precisely delineate the dynamic regulatory networks of cardiac metabolic reprogramming, coupled with developing therapies targeting critical metabolic nodes, represents a core challenge in advancing precision medicine for CVDs

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