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These rats were fed a high-fat diet, but the supplementation prevented significant increases in body weight gain and body fat mass compared with nontreated animals

The invasion of cancer cells is also influenced by glutamine metabolism

Further, icariside II significantly increases the phosphorylation levels of ERK1/2, Akt and JNK1/2 suggesting that the Nrf2/ARE pathway plays an important role in the regulation of icariside-mediated antioxidant effects in HepG2 cells [45]

When combined with lifestyle interventions like reduced-calorie diets and exercise, these mechanisms may accelerate visible changes in energy and body composition

Subsequently, the RAW264.7 cells were washed with PBS and stained by Ca 2+ Probe Fluo-4 AM for 20 min

Talanta 230 , 122337 (2021)