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The polyamine pathway influences cell replication / regeneration, DNA synthesis , and apoptosis and yields an important metabolite methylthioadenosine (plays a pivotal role in hepatocyte function and gene transcription)

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However, the efficacy of small molecule inhibitors targeting NNMT remains uncertain due to their lack of selectivity and low metabolic stability (Iyamu and Huang, 2021)

PMID: 452623, PMCID: PMC2595701

The same goes for other autoimmune conditions, like type 1 diabetes or autoimmune thyroid disease

Directions: Adults: Chew and dissolve 1 tablet in the mouth or under the tongue 1-2 times a day before meals in the morning or 2-3 hours after dinner, or as directed by your healthcare professionals