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Given the role of angiogenesis in the growth and/or maintenance of neurovascular units in the nervous system, a role for abnormal angiogenesis in neurodegenerative diseases has been hypothesized and aberrant angiogenesis has been proposed as a potential factor in the progression of neurodegenerative diseases (Parkes et al

Mice with hypertension induced by a high-salt and angiotensin II-based diet showed reduced proteinuria and blood pressure when IL-6 was knocked out (138)

reported that cord blood-derived multipotent stem cells (CB-SCs) inhibited CD8 + NKG2D + T cell proliferation through HVEM/BTLA and PD-L1/PD-1 signaling pathways [49]

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In vivo implantation effectively restored disc height and preserved structural and functional integrity for 4 weeks, confirming significant regenerative efficacy