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1,2,6 Skin hyperpigmentation, glossitis, and infertility have also been reported

However, modern advancements in supplement formulation have significantly improved the bioavailability of oral B12, making it a more effective option than ever before

These vitamins work together to help brain and body cells produce SAM-e, a hormone important to neurotransmitter function and mood health

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Some studies have shown that, if people with Down syndrome take the inactive oral forms of vitamin B12 and folate, their bodies may have difficulty converting from the inactive to the active form and the inactive form may not be as effective