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Wong W et al

Funding This work was financially supported by the National Natural Science Foundation of China (Grants 82170642, 82172754, 81874208, 22405079) and the Opening Project of Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients (HLPAI2023001)

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Since the mitochondrial [NAD + ], which is present at a concentration of 150250 M (Sallin et al., 2018), is roughly 15100-fold higher than the mitochondrial [NADP + ], which is present at a concentration of 210 M, the extent of astrocytic mitochondrial NADPH generated by GLUD1 during normal ad libitum feeding conditions may only be moderate