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Functional expression of two system A glutamine transporter isoforms in rat auditory brainstem neurons

303 Additionally, inhibition of mitochondrial respiration failed to rescue the ES/Cu toxicity, 303 and intracellular copper can be released from the ES/Cu complex and become bioavailable outside the mitochondria, suggesting a great likelihood of mitochondrial-independent cuproptosis

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[19] Augmentation [edit] If therapy with antidepressants (such as selective serotonin reuptake inhibitors [SSRIs]) does not fully treat and discontinue [38] the symptoms of major depressive disorder (MDD) (also known as refractory depression or treatment resistant depression [TRD]) [39] then a second augmentation agent is sometimes added to the therapy

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Doctors usually begin with a low dose of semaglutide, such as 0.25 mg, given once a week as a subcutaneous injection