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However, species differences limit direct extrapolation

Rights and permissions About this article Cite this article Popma, A., Doreleijers, T., Jansen, L

Evidence source : NEJM (2023 Phase 2), Novo Nordisk trials (NCT04982530)

Therefore, a decrease of oxidative stress markers in heart mitochondria under the conditions of administration of glutathione to old animals shows the antioxidative effects of this compound and the important role of sufficient levels of GSH in the maintenance of redox status of old rat heart mitochondria

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