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The authors suggested that environmental factors, such as ambient temperature, may modulate hypothalamic-pituitary-thyroid axis activity, contributing to fluctuations in disease activity or laboratory values in patients with Hashimotos thyroiditis, highlighting the importance of considering the seasonal context in the diagnosis and treatment of thyroid disorders.Finally, living in overly sterile environments with limited exposure to environmental agents has been linked to a higher incidence of HT, possibly due to reduced immune system training and altered microbiota composition (Klubo-Gwiezdzinska And Wartofsky 2022)

The other phenolic substances identified in the composition included hydroxycinnamic acid, which accounted for 2.6% of the total phenolics

Moreover, in these cells, we observed significant upregulation of mesenchymal markers FN1, N-cad, and Twist (Fig

Mizuno, M., Sakaguchi, K., & Sakane, I

Li Q, Zhang M, Sun J, Li Y, Zu S, Xiang Y, et al

Quercetin is available as a dietary supplement in doses of 500 to 1000 mgs and the amount we get in our diets is considerably less (~100 mg)