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Rigorous experimental protocols were adhered to during data collection and analysis, providing novel insights into the field of PE+

Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet

More critically, the human population exhibits three distinct ApoE isoforms with markedly divergent LDLR-binding properties, humans exhibit three isoforms (ApoE2, ApoE3, ApoE4) with markedly different LDLR-binding affinities: ApoE2 binds to LDLR with 50- to 100-fold weaker affinity than ApoE3 or ApoE4, potentially impairing LNP uptake in ApoE2 carriers [142]

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Autophagy also shares machinery with endocytic-like pathways such as LC3-associated endocytosis and LC3-associated phagocytosis, where components of the LC3-conjugation system (but not the entire broader canonical autophagy machinery) are co-opted to these vesicles