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JAMA 311 , 16701683

These results suggest that ACE elevates Fe 2+ levels to induce ferroptosis in colorectal cancer through direct binding to PCBP1 and PCBP2

Some immune suppressive cells, such as regulatory T cells (Tregs), 229 can inhibit the activity of other immune cells by activating the NF-B pathway, maintaining immune balance and self-tolerance

Iyer PC, Dadu R, Gule-Monroe M, Busaidy NL, Ferrarotto R, Habra MA, Zafereo ME , Williams MD, Gunn GB, Grosu H, Skinner HD, Sturgis EM, Gross N, Cabanillas ME