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Prescription Required: Yes (if used as actual injection form) / No (if oral supplement variant)

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Limitations of Use: Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration and persist over the course of therapy [see WARNINGS], reserve opioid analgesics, including oxycodone and acetaminophen tablets, for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain

Venlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study