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3.3.1 Ferroptosis inducers Small molecules targeting iron metabolism: Erastin was first identified in 2003 as a genetically selective antitumor agent that induces ferroptosis primarily through interaction with VDACs (120)

The expression of GSTF8 and GSTU19 was significantly lower in Atgstf8 and Atgstu19 mutants, respectively

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Ergosterol starts from acetyl-CoA and is synthesized by nearly 30 proteases, ergosterol esters/sterol esters (SE) are formed by the action of fatty acyl-CoA and ergosterol/sterols under the action of sterol acyltransferases (ARE1/ARE2) (Koch et al., 2014)

Furthermore, the concept of hybrid insulin peptides (HIPs) is an active area of investigation, particularly in type 1 diabetes