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Castro-Snchez et al.s study demonstrated that in Cx3cr1 / mice overexpressing -syn A53T , neurodegeneration, neuroinflammation, and microglial activation were significantly enhanced (191)

Two studies from two different institutions recently identified a novel iron death signaling pathway independent of GPX4 (Bersuker et al., As an essential intracellular antioxidant, reduced glutathione (-L-glutamyl-L cysteinylglycine, GSH) synthesis requires the cystine/glutamate antiporter system (encoded by SLC7A11 ) to import cystine from the environment and reduce it to cysteine

BMC developmental biology

22q11.2DS is characterized by neuropsychiatric abnormalities, such as schizophrenia [357], attention-deficit hyperactive disorder, anxiety, depression, and ASD [358]

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