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Glyoxalase 1 as a Therapeutic Target in Cancer and Cancer Stem Cells

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10.1158/2326-6066.CIR-14-0232 [DOI] [PMC free article] [PubMed] [Google Scholar] 113.Shiao SL, Kershaw KM, Limon JJ, You S, Yoon J, Ko EY, et al

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Key findings included: Statistically significant erectile responses at doses above 7 mg compared to placebo Onset of first erection occurring approximately 30 minutes post-administration Mean duration of adequate erection rigidity increasing from 18 minutes to 73 minutes at higher doses Efficacy in approximately one-third of men who had inadequate response to sildenafil Studies using subcutaneous administration (1.0-10.0 mg) in men with inadequate Viagra response demonstrated dose-dependent improvements in penile rigidity and erectile function