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Proline is exceptional in that it has an R group that folds back and covalently bonds to the backbone of the amino acid, creating a more rigid element in a protein chain that reduces free movement of the polypeptide chain

AXL participates in the appearance of CD11 c high spinal dorsal horn microglia to induce the expression of IGF-1, promoting the relief of PNI induced neuropathic pain[35]