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Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition

10.1111/j.1471-4159.1989.tb09150.x J

Wu H, Deng Y, Feng Y, Long D, Ma K, Wang X, Zhao M, Lu L, Lu Q

In summary, adipose tissue dysfunction, hepatocellular metabolic stress, cell death, and gut-derived stimuli converge from the early stages of disease to activate hepatic immune cells and determine their behavior

G.DaviesP

Huang Y, Jiang Y, Xiao Z, Shen Y, Huang L, Xu X, et al