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For semaglutide-related reflux that does not respond to H2 blockers, an 8-week course of a PPI is the standard recommendation

People with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2) should not use GLP-1 receptor agonists because of potential tumor risks observed in animal studies

Do not self-administer this medicine at home

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Singly-housing animals, which prevents inter-animal coprophagy, reduces beta diversity of the microbiome compared to stressful (chronic subordinate colony) co-housing conditions 72

Thats because they work very well to support weight loss - better than diet and exercise changes alone, in fact