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Formation of hypothalamic regulation of the gonadotropic function of the hypophysis under the conditions of hypoinsulinemia in rats

analyzed the expression of HOXA10 and integrin beta-3 (ITGB3) in the endometrium of individuals treated with metformin compared to a control group, as well as the regulatory influence of miRNAs, miR-1910-3p and miR-491-3p, on HOXA10 and ITGB3

The preventive effect could be attributed to its active phytochemicals including flavonoids, terpenes, coumains, saponins, alkaloids, sterol, and tannins [11]