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Nature 571 , 403407 (2019)

3.2 TCA cycle dysregulation and accumulation of metabolic intermediates Dysregulation of key enzymes in the TCA cycle leads to abnormal accumulation of metabolic intermediates, further disrupting insulin signaling ( + , is facilitated by the high membrane potential (m) and succinate-driven reduction through complex II

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GH and IGF-1 directly affect growth plates

Proc Natl Acad Sci U S A 113:E4966-4975 Long H, Zhu W, Wei L, Zhao J (2023) Iron homeostasis imbalance and ferroptosis in brain diseases

Jan 32025 CJC1295 is a synthetic growth hormone-releasing (GHRH) peptide that is comprised of 30 amino acids