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During treatment, a small amount of blood (typically 4060 cc) is withdrawn and treated with medical ozone and ultraviolet (UV) light before being reinfused into the body over approximately 2030 minutes

In conclusion, naturally derived bioactive compounds represent a valuable frontier in asthma research, offering mechanistically distinct approaches to addressing the underlying pathophysiology of the disease

Notably, conversion of aconitate to itaconate via aconitate decarboxylase (ACOD1) that activates downstream KEAP1/NRF2 signaling and inflammatory response pathway are well known under inflammatory conditions 103,104

Thus, PMRS in RBCs may act as a compensatory mechanism against increased ROS/oxidative stress and represents a potential mechanism of how RBCs contribute to redox regulation throughout the whole body (173)

HMGB1 is involved in autophagy inhibition caused by SNCA/-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B