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SIRT4 hydrolyzes the lipoamide cofactors from the E2 component dihydrolipoyllysine acetyltransferase (DLAT), leading to diminished PDH activity

81 Jafarzadeh BejargafsheM.HedayatiM.ZahabiasliS.TahmasbpourE.RahmanzadehS.Nejad-MoghaddamA

& Bubeck Wardenburg, J

So when the mitochondria fail, it doesnt do a job

Concentrations of ACT were optimized to impair to the same extent as in HEK293 treated with 15 M ACT (loss of 40% growth)

J Agric Food Chem 44:33353341 Google Scholar Mitchell, G, Bartlett, DW, Fraser, TEM, Hawkes, TR, Holt, DC, Townson, JK Wichert, RA (2001) Mesotrione: a new selective herbicide for use in maize