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Some patients schedule treatments occasionally, while others incorporate IV therapy into ongoing wellness routines

Am J Physiol Lung Cell Mol Physiol 1999, 277 (1 Pt 1) : L113118

Lancet 388 , 706716 (2016)

By avoiding established pharmacological treatments that may produce significant side effects, parents try to alleviate behavioral problems and associated comorbid conditions using alternative treatments

Bertrand, J

Interestingly, targeting PDK with the prototypic drug, dichloroacetate (DCA, a structural analog of pyruvate), lowers phosphorylation on the E1 subunit which ultimately improves PDH activity and lowers blood lactate levels