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Diospyros kaki extracted a rich source of flavonoids and polyphenols, showed significant improvements in tear volume and tear film stability, indicated by prolonged break-up time (BUT) and reduced fluorescein staining scores, demonstrating a decrease in corneal epithelial damage compared to untreated BAC controls

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Further evidence for this hypothesis comes from recent yeast two-hybrid studies performed with enzymes from sweet peony, where the arGST Ps GSTF3 was found to interact with Ps DFR, the dihydroflavonol reductase catalysing the formation of 3,4- cis -leucocyanidin ( 6 ) 47

Some studies have found that oral iron chelators, like deferiferrin, have limited or no effect on improving motor function after SCI (130, 131)

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