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The incidence of DPN is associated with hyperglycemia and cardiovascular risk factors such as raised cholesterol, triglycerides, hypertension, obesity, and smoking, which can be modulated by early intervention

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Zn promotes the expression of ZFPs with anti-inflammatory properties, such as A20, which hinders the activity of NF- and NF- target genes, such as IL-1 and TNF, and thus prevents TNF-induced programmed cell death (113, 114)