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Au niveau molculaire, diffrents mcanismes pro-apoptotiques ont t mis en vidence : mort cellulaire par autophagie via un dysfonctionnement mitochondrial ROS-dpendant (rduction du potentiel de membrane) et libration de cytochrome C

(Riederer 2022) Other pathways involve CYP2C8 and CYP2B6

68 Furthermore, that study had also enrolled children who had presented to the hospital with accidental APAP overdose, and thus applicability to the adult population may be better reserved for a time after other studies are completed with a greater adult population

Lab-on-a-chip platforms complement microfluidic synthesis by providing biomimetic evaluation of transport, penetration, and response, facilitating patient-derived assays, increasing fidelity, lowering costs, and enhancing translational potential