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In a study by Yang et al., Wistar rats were intratracheally instilled with NiO NPs suspensions at doses of 0.015, 0.06, and 0.24 mg/kg, administered twice a week for 9 weeks [122]

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Hasan M, Messaoud GB, Michaux F, Tamayol A, Kahn CJ, Belhaj N, Linder M, Arab-Tehrany E

Yet, after over a century of research, the penultimate biosynthetic step to anthocyanidins attributed to the action of leucoanthocyanidin dioxygenase has never been efficiently reconstituted outside plants, preventing the construction of heterologous cell factories

doi: 10.1016/j.cmet.2011.08.016, 20 BergersenL