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Future translational efforts should pursue several directions: first, conducting deep-phenotyping trials in biopsy-confirmed MASH patients, using positron emission tomography to quantify hepatic glucose uptake and correlating these findings with intrahepatic insulin signaling (e.g., p-AKT)

P Mackenzie Ventura, Riverdale, Sr

M., Coskun, E., Weeghel, M

T., Drummer, O

As such, while short-term, targeted use appears beneficial, further studies are needed to evaluate whether prolonged application maintains its ergogenic effects or if periodic cycling of supplementation is advisable to prevent plateauing of performance benefits