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But it must be acknowledged that, like heavy metals, excessive concentrations of metal ions from the aforementioned metals can induce various forms of cellular damage and apoptosis, resulting in increased wound inflammation and oxidative stress responses (Song et al., 2019)

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doi: 10.1161/circulationaha.122.060257 35 ShahRShchepinovMSPrattDA

In contrast, synthetic, proliferative VSMCswhich dominate pathologies such as atherosclerosisundergo a metabolic shift toward glycolysis and possess reduced antioxidant defenses, rendering them highly vulnerable to cuproptosis [154, 155]

This serves two vital purposes: Protection: The phospholipid shell acts as a shield