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2021, 6 (1), ysab017

Additionally, triptolide promotes apoptosis and inhibits metastasis in glioblastoma cells in a dose-dependent manner by upregulating p21 and Bax protein expression while suppressing MMP-2 and MMP-9 protein levels, with PROX1 transcriptional inhibition elucidated as a mechanistic pathway, while in NSCLC, triptolide induces apoptosis and mitigates metastasis by targeting the IL-6/STAT3 signaling axis, characterized by reduced STAT3 phosphorylation and downregulation of STAT3 target genes, including c-Myc, Bcl-2, Mcl-1, and MMP-9, which are implicated in cell survival and migratory processes [978, 1013]

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A Quick Reminder About the July PCAC Meeting The meeting will address seven peptide families

doi: 10.1016/J.TCM.2021.09.009 144 Fernndez-De-las-peasCMartn-GuerreroJDPellicer-ValeroOJNavarro-PardoEGmez-MayordomoVCuadradoMLet al

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