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10.1007/s10592-015-0775-4 24 BayoumiE

The angiogenic effect of copper has been well-recognized, which is presumed to attribute to the regulation of factors involved in vessel formation and maturation, especially the pro-angiogenic factor, namely vascular endothelial growth factor (VEGF), and its major transcription factor, namely hypoxia-inducible factor-1-alpha (HIF1) [36]

Moreover, boosting intracellular NAD + levels using anti-CD38 antibody enhanced antitumor properties of hybrid Th1/17 cells through the upregulation of NAD + -SIRT1-FOXO1 axis [123, 124]

Peripheral IL-6 and TNF- stimulate endothelium and perivascular cells, causing CNS glial activation without cell invasion [93]

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[9] Chemistry methods were widely-used, including oxygen radical absorbance capacity (ORAC) [10] , total radical-trapping antioxidant parameter (TRAP) [11] , Trolox equivalent antioxidant capacity (TEAC) [12] , total oxyradical scavenge capacity (TOSC) [13] , the peroxyl scavenging capacity (PSC) [14] , the ferric reducing/antioxidant power assay (FRAP) [15] , and the DPPH free radical method [16]