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Concurrently, we assessed the Nrf-2/HO-1 antioxidant pathway (Figures 4E,J,K)

However, in the context of the surgical samples in this study, we lack controls

However, several challenges complicate this intervention: Donor liver availability: The rising prevalence of obesity and diabetes has increased the incidence of hepatic steatosis among potential donors, thereby limiting the pool of acceptable grafts

MOTS-c has shown promise in promoting healthy aging, as it may reduce inflammation, improve physical endurance, and optimize metabolic functions, contributing to better overall health and longevity

Though ellagitannins seem to be the dominant phenolics of SB leaves, considerable amounts of saponins can be found in the seeds and leaves, and triterpenoids occur in all parts of this plant, these compounds were relatively rarely investigated (especially ellagitannins and saponins), as compared to SB flavonoids, phenolic acids, or carotenoids