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While imaging cannot exclude all forms of the disease, it plays an increasingly important role in supporting a presumptive clinical diagnosis and guiding management without immediate surgical confirmation

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2013;2:e28

Enzymatic demethylation of 7,8-dihydromethysticin followed by ring opening of the alpha-pyrone ring, and rearrangement was suggested to contribute to the formation of highly GSH reactive metabolite 6-phenyl-3-hexen-2-one as its mercapturic acid adduct found in human urine [43]

NSAIDs are also widely used for their anti-inflammatory properties but act in a different way