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The answer is nuanced

103 , R15R21 (1999)

According to various studies, up to 85 percent of patients with vitamin B12 deficiency experience at least one neurological symptom

The lack of statistical significance in sensitivity analyses stratified by other ARV use may be attributed in part to the small sample sizes, especially in the groups who used TDF and/or EFV before switch only ( n = 8), who used TDF and/or EFV before and TDF after switch ( n = 27), who did not use any INSTI or TAF ( n = 18), and who used TAF without any INSTIs ( n = 28)