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In fact, the cysternae of the endoplasm reticulum is the only part of the cell with a relatively high ratio of GSSG/GSH

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It also causes a decrease in the expression of cyclin D1, which plays a role in cell proliferation [182]

As SHMT2 is the main cancer-related enzyme responsible for ser/gly conversion and downstream synthesis of the pyrimidine nucleotide TMP, we measured SHMT2 protein expression by flow cytometry in response to irradiation across a NSCLC cell panel ( n = 6)