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4.2 Targeting mtROS to improve tumor immunotherapy Since ROS in tumor cell mitochondria have been shown to play an important role in immunotherapy, how mitochondrial targeted drugs can promote tumor cells to produce excessive ROS, damage mtDNA, release immunogenic intracellular substrates, and activate anti-tumor immunity are important areas of focus in anti-tumor research ( Figure 9 )

monthly) to assess progress and any side effects

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GSH and GSSG contents in liver was assessed by HPLC, as described by Cruzat and Tirapegui (2009)