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Perhaps the most practical notion of whether a diet can be considered to be ketogenic is made by Seyfried (2012): it is as long as the individual has reduced blood glucose and is producing ketones. Although protein is included in the ketogenic ratio equation (Shaffer, 1921), glucose, ketone bodies, and their interplay determine the dominating metabolic mode: whether the predominant energy supply is glucose or ketone bodies (Westman et al., 2003)

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ATRA-PLGA NPs could target and be delivered to THP-1 cells in large quantities, leading to inhibition of H37Ra MTB proliferation in macrophages in a dose-dependent manner