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Despite adenosine-dependent induction of gpx1 in human primary endothelial cells and cellular protection against oxidative stress (33), we found that treatment with A2ARi or the A2AR agonist CGS 21680 altered the gene expression of gpx4 but not gpx1 (Supplemental Figure 8D) determined by RT-qPCR, indicating the importance of A2AR-mediated signaling in specific regulation of gpx4 transcripts in activated CD8 + T cells

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(2009) 4:e4715

Holland, W

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