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Same total amount, just spread out

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37,38 In one prospective, multicenter study of patients with biopsy-proven CLE unresponsive to at least three systemic therapies, including belimumab, all patients achieved a 50% reduction in CLASI-A (CLASI-A-50) at Week 16, highlighting the potential utility of anifrolumab even in highly treatment-resistant disease

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Shock 16:373379 Jia G, Cheng G, Gangahar DM, Agrawal DK (2006) Insulin-like growth factor-1 and TNF-alpha regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells

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