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The honest research caveat is that "theoretically additive" is not "experimentally additive" and a researcher who needs to claim synergy must run the combination versus the components in their own model

de Wit, E

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It was my turn to get kicked out of the chat room, so I hope Im not repeating what Dave was saying, because I missed all of that, but I think this is really interesting, and I think, just like all of you guys get this question a lot, especially within the last year or so, and like you said, people are taking this

So few documented side effects mainly reflects absence of rigorous data , not proof of safety