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p62 binds directly to LC3 to deliver selective autophagic cargo for degradation via autophagy [83]

[DOI] [PubMed] [Google Scholar] 148.Appel L.J., Moore T.J., Obarzanek E., Vollmer W.M., Svetkey L.P., Sacks F.M., Bray G.A., Vogt T.M., Cutler J.A., Windhauser M.M., et al

This roughly represents a doubling of the absolute and relative number of deaths (1.4 million deaths from ASCVD, 11% of all deaths) compared to 1990 (Zhao et al., 2019)